Bovine tuberculosis is one of the chronic bacterial diseases of animals that can acquire a variable amount of time (from a few weeks to a lifetime) to expand from infection to clinical disease and to happen to infectious to other animals. Mycobaterium bovis has a remarkably wide range of mammalian hosts and affect all age groups of susceptible hosts of domestic, wild animals and human. Numerous studies undertaken in diverse parts of the country have deep-rooted the widespread nature of the disease in Ethiopian cattle p populations. More to the point being a potential zoonotic danger through consumption of raw animal foodstuffs and close animal-human contact, the disease can have chief economic impacts on national livestock sector. Regardless of the isolation of M. bovis from domestic animal and human, no infection due to M. bovis was reported in Ethiopian wildlife populations so far and the burden of the disease in wildlife populations is yet unfamiliar. Therefore, objectives of this review paper is to elaborate the epidemiological interface of M. bovis in wildlife, livestock and human in Ethiopia, to identify risk factors considered in studies conducted so far in Ethiopia. Diseases transmitted between humans, livestock, and wildlife are progressively more challenging public and veterinary health systems. Therefore, studies concerning the burden of the diseases in wildlife, livestock and human beings in Ethiopia should be undertaken.